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FAQ
Anti-Mouse CD22 Monoclonal Antibody(APC Conjugated)
| Product name: | Anti-Mouse CD22 Monoclonal Antibody(APC Conjugated) | |
| Catalog: | DL20376F |
|
| Synonyms : | B-cell receptor CD22,Cd22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14,CD22,Lyb-8, Siglec2 | |
| Reactivity: | Mouse | |
| Applications: | FCM | |
| Size: | 25 ug/50 ug/100 ug/200 ug | |
| Host: | Mouse | |
| Clonality: | ||
| Conjugation: | ||
| Background: | The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig ?? chain are augmented in the presence of Cy34.1 mAb. |
|
| Concentration: | 0.2 mg/mL | |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA | |
| Gene_ID: | 12483 | |
| Clone_NO: | Cy34.1 | |
| SwissProt: | P35329 | |
| Isotype: | Mouse IgG1, ? | |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. | |
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