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FAQ
Anti-Mouse CD115 Monoclonal Antibody(APC Conjugated)
| Product name: | Anti-Mouse CD115 Monoclonal Antibody(APC Conjugated) | |
| Catalog: | DL21295F |
|
| Synonyms : | Macrophage colony-stimulating factor 1 receptor,CSF-1 receptor (EC:2.7.10.1),CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,CD115,Csf1r,Csfmr,Fms | |
| Reactivity: | Mouse | |
| Applications: | FCM | |
| Size: | 50 Tests/100 Tests/500 Tests/ | |
| Host: | Rat | |
| Clonality: | ||
| Conjugation: | ||
| Background: | CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. |
|
| Concentration: | ||
| Buffer: | PBS with 0.05% Proclin300, 1% BSA | |
| Gene_ID: | 12978 | |
| Clone_NO: | AFS98 | |
| SwissProt: | P09581 | |
| Isotype: | Rat IgG2a, ? | |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. | |
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