Anti-Human CD196/CCR6 Monoclonal Antibody(FITC Conjugated)

Product name:	Anti-Human CD196/CCR6 Monoclonal Antibody(FITC Conjugated)
Catalog:	DL21844F
Synonyms :	CKRL3, CMKBR6, GPR29, STRL22,GPRCY4
Reactivity:	Human
Applications:	FCM
Size:	20 Tests/50 Tests/100 Tests/200 Tests
Host:	Mouse
Clonality:
Conjugation:
Background:	CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the ?? defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.
Concentration:
Buffer:	PBS with 0.05% Proclin300, 1% BSA
Gene_ID:	1235
Clone_NO:	G034E3
SwissProt:	P51684
Isotype:	Mouse IgG2b, ?
Storage:	Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.

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DL21844F