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FAQ
Anti-Human Notch3 Monoclonal Antibody(PE Conjugated)
| Product name: | Anti-Human Notch3 Monoclonal Antibody(PE Conjugated) | |
| Catalog: | DL21926F |
|
| Synonyms : | NOTCH3,Notch 3,Notch 3 extracellular truncation,Notch 3 intracellular domain | |
| Reactivity: | Human | |
| Applications: | FCM | |
| Size: | 20 Tests/50 Tests/100 Tests/200 Tests | |
| Host: | Mouse | |
| Clonality: | ||
| Conjugation: | ||
| Background: | The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome. |
|
| Concentration: | ||
| Buffer: | PBS with 0.05% Proclin300, 1% BSA | |
| Gene_ID: | 4854 | |
| Clone_NO: | MHN3-21 | |
| SwissProt: | Q9UM47 | |
| Isotype: | Mouse IgG1, ? | |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. | |
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