AF/LE Purified Anti-Human CD274/PD-L1 Monoclonal Antibody

Product name:	AF/LE Purified Anti-Human CD274/PD-L1 Monoclonal Antibody
Catalog:	DL21663F
Synonyms :	B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Reactivity:	Human
Applications:	Block, FA, FCM, IHC
Size:	50 ug/500 ug/1 mg/
Host:	Mouse
Clonality:
Conjugation:
Background:	CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-?? production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
Concentration:	0.2 mg/mL
Buffer:	0.2 um filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/ug) as Determined by LAL gel clotting assay.
Gene_ID:	29126
Clone_NO:	29E.2A3
SwissProt:	Q9NZQ7
Isotype:	Mouse IgG2b, ?
Storage:	Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.

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DL21663F