AF/LE Purified Anti-Human CD279/PD-1 Monoclonal Antibody

Product name:	AF/LE Purified Anti-Human CD279/PD-1 Monoclonal Antibody
Catalog:	DL22249F
Synonyms :	PDCD1,PD1,Protein PD-1,hPD-1
Reactivity:	Human
Applications:	FCM
Size:	50 ug/500 ug/1 mg/
Host:	Mouse
Clonality:
Conjugation:
Background:	Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
Concentration:	0.2 mg/mL
Buffer:	0.2 um filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/ug) as Determined by LAL gel clotting assay.
Gene_ID:	3683
Clone_NO:	J110
SwissProt:	P20701
Isotype:	Mouse IgG1, ?
Storage:	Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.

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DL22249F