Anti-Human/Mouse/Rat Foxp3 Monoclonal Antibody(PE/Cyanine5 Conjugated)

Product name:	Anti-Human/Mouse/Rat Foxp3 Monoclonal Antibody(PE/Cyanine5 Conjugated)
Catalog:	DL22207F
Synonyms :	Forkhead box protein P3,IPEX,JM2,Foxp3
Reactivity:	Human, Mouse, Rat
Applications:	ICFCM
Size:	20 Tests/50 Tests/100 Tests/200 Tests
Host:	Mouse
Clonality:
Conjugation:
Background:	FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 ??2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.
Concentration:
Buffer:	PBS with 0.05% Proclin300, 1% BSA
Gene_ID:	5,094,320,371,317,380
Clone_NO:	150D
SwissProt:	Q9BZS1,Q99JB6
Isotype:	Mouse IgG1, ?
Storage:	Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.

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DL22207F