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FAQ
ER780 Anti-Human CD8a Antibody
| Product name: | ER780 Anti-Human CD8a Antibody | |
| Catalog: | DL22858F |
|
| Synonyms : | T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL | |
| Reactivity: | Human | |
| Applications: | FCM | |
| Size: | 20Tests | |
| Host: | Mouse | |
| Clonality: | ||
| Conjugation: | ||
| Background: | CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
|
| Concentration: | ||
| Buffer: | PBS with 0.05% Proclin300, 1% BSA | |
| Gene_ID: | 925 | |
| Clone_NO: | ||
| SwissProt: | P01732 | |
| Isotype: | Mouse IgG2a, κ | |
| Storage: | Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. | |
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