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FAQ
EV450 Anti-Mouse CD45R/B220 Antibody
| Product name: | EV450 Anti-Mouse CD45R/B220 Antibody | |
| Catalog: | DL22862F |
|
| Synonyms : | B220 | |
| Reactivity: | Mouse | |
| Applications: | FCM | |
| Size: | 25μg | |
| Host: | Rat | |
| Clonality: | ||
| Conjugation: | ||
| Background: | CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity. |
|
| Concentration: | 0.5 mg/mL | |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA | |
| Gene_ID: | 19264,5788 | |
| Clone_NO: | ||
| SwissProt: | ||
| Isotype: | Rat IgM, κ | |
| Storage: | Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. | |
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