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FAQ
AF647 Anti-Mouse CD274/PD-L1 Antibody
| Product name: | AF647 Anti-Mouse CD274/PD-L1 Antibody | |
| Catalog: | DL22935F |
|
| Synonyms : | B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1 | |
| Reactivity: | Mouse | |
| Applications: | FCM | |
| Size: | 20Tests | |
| Host: | Rat | |
| Clonality: | ||
| Conjugation: | ||
| Background: | CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production. |
|
| Concentration: | ||
| Buffer: | PBS with 0.05% Proclin300, 1% BSA | |
| Gene_ID: | 60533 | |
| Clone_NO: | ||
| SwissProt: | Q9EP73 | |
| Isotype: | Rat IgG2b, κ | |
| Storage: | Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. | |
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