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FAQ
Purified Anti-Human CD279/PD-1 Monoclonal Antibody
| Product name: | Purified Anti-Human CD279/PD-1 Monoclonal Antibody | |
| Catalog: | DL22250F |
|
| Synonyms : | PDCD1,PD1,Protein PD-1,hPD-1 | |
| Reactivity: | Human | |
| Applications: | FCM, IHC | |
| Size: | 25 ug/100 ug | |
| Host: | Mouse | |
| Clonality: | ||
| Conjugation: | ||
| Background: | Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
|
| Concentration: | 0.2 mg/mL | |
| Buffer: | PBS with 0.05% Proclin300 | |
| Gene_ID: | 3683 | |
| Clone_NO: | J110 | |
| SwissProt: | P20701 | |
| Isotype: | Mouse IgG1, ? | |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. | |
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