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FAQ
Purified Anti-Mouse CD45R/B220 Monoclonal Antibody
| Product name: | Purified Anti-Mouse CD45R/B220 Monoclonal Antibody | |
| Catalog: | DL21361F |
|
| Synonyms : | B220,CD45,GP180,LCA,T200 | |
| Reactivity: | Mouse | |
| Applications: | FCM, IHC, IP | |
| Size: | 50 ug/100 ug | |
| Host: | Rat | |
| Clonality: | ||
| Conjugation: | ||
| Background: | CD45, also known as leukocyte common antigen (LCA), B220, and T200, is a 180-2CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.40 kD single chain type I membrane glycoprotein. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 is one of the best negative selection markers for characterizing and/or isolating human mesenchymal stem cells from bone marrow and other sources. |
|
| Concentration: | 0.2 mg/mL | |
| Buffer: | PBS with 0.05% Proclin300 | |
| Gene_ID: | 192,645,788 | |
| Clone_NO: | RA3.3A 1/6.1 | |
| SwissProt: | P06800,P08575 | |
| Isotype: | Rat IgM | |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. | |
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