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FAQ
Purified Anti-Human CD28 Monoclonal Antibody
| Product name: | Purified Anti-Human CD28 Monoclonal Antibody | |
| Catalog: | DL22136F |
|
| Synonyms : | PAS2,MNS,HGpMiX,GYPA,GPSAT | |
| Reactivity: | Human | |
| Applications: | FCM,IHC,IP | |
| Size: | 25 ug/100 ug | |
| Host: | Mouse | |
| Clonality: | ||
| Conjugation: | ||
| Background: | CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. |
|
| Concentration: | 0.2 mg/mL | |
| Buffer: | PBS with 0.05% Proclin300 | |
| Gene_ID: | 940 | |
| Clone_NO: | CD28.2 | |
| SwissProt: | P10747 | |
| Isotype: | Mouse IgG1, ? | |
| Storage: | Store at 2~8℃. Do not freeze. | |
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