Acetylcholine (ACh)
Acetylcholine (ACh) is a neurotransmitter that can specifically act on various types of cholinesterase receptors and is quickly destroyed by cholinesterase in tissues. Its effects are extensive and its selectivity is not high. Clinical inutility.
In nerve cells, acetylcholine is synthesized by choline and acetylcoa catalyzed by the cholinergic acetyltransferase (cholinergic acetyltransferase). Because the enzyme is present in the cytoplasm, acetylcholine is synthesized in the cytoplasm, which is then ingested and stored by vesicles. The synthesis of norepinephrine takes tyrosine as the raw material. Firstly, dopamine is synthesized under the catalysis of tyrosine hydroxylase. Dopamine is then ingested into the vesicles, where it is further synthesized and stored in the vesicles, catalyzed by dopamine neurohydroxylase. Dopamine synthesis and norepinephrine 2 steps before Daniel people is exactly the same, just no longer after dopamine into vesicles synthesis of norepinephrine, because stored within the small Tang dopamine excluding beta hydroxylase dopamine. The synthesis of 5-hydroxytryptophan takes tryptophan as the raw material. First, 5-hydroxytryptophan is synthesized under the action of tryptophan hydroxylase, and then 5-hydroxytryptophan is synthesized under the action of 5-hydroxytryptophan (amino acid desatase). The two steps are performed in the cytoplasm. Serotonin is then ingested and stored in vesicles. Decarboxylated isobutyric acid was synthesized by glutamic acid catalyzed by decarboxylation of glutamic acid. The full complement of peptide transmitters is exactly the same as the synthesis of other peptide hormones, which are regulated by genes and produced by translation on ribosomes.
Once the acetylcholine that enters the synaptic gap ACTS on the postsynaptic membrane, it is hydrolyzed by the cholinesterase to form choline and acetic acid, which is then destroyed and promoted, a process called inactivation. After norepinephrine enters the synaptic space and plays a physiological role, part of it is taken away by blood circulation and then damaged and inactivated in the liver. The other part is destroyed inactivation by the action of catecholamine and monoamine oxidase in effector cells. But the presynaptic membrane, for the most part, restores norepinephrine into the axoplasm of the presynaptic membrane and reuses it.
The brain has a lot of acetylcholine, but the level of it goes down with age. Normal older adults have a 30 percent decrease compared to young adults, while alzheimer's patients have a more severe decline, up to 70 to 80 percent. American doctor wootman observed a decrease in acetylcholine in the brain tissue of the elderly and gave them foods rich in choline. Scientists in countries such as the UK and Canada have also carried out research which shows that if enough choline is supplied in a controlled manner, memory loss in people aged around 60 can be prevented. So maintaining and increasing the amount of acetylcholine in the brain is a fundamental way to address memory loss. In nature, acetylcholine is mostly present in eggs, fish, meat and soybeans in the state of choline. These choline must undergo biochemical reactions in the human body before they can be synthesized into the biologically active acetylcholine. In addition, regular use of royal jelly can improve the content of acetylcholine in the brain, thereby promoting the activation of brain nerve conduction function, improving information transmission speed, enhancing brain memory ability, comprehensively improving brain function and delaying aging.
At present, DLDEVELOP co. LTD has developed corresponding ACH Elisa products. To get more information, you could contact our professional staff directly or directly to our website:
https://dldevelop.com/Research-reagent/dl-ach-ge.html
https://www.dldevelop.com/uploadfile/data/DL-ACH-Ge.pdf
In nerve cells, acetylcholine is synthesized by choline and acetylcoa catalyzed by the cholinergic acetyltransferase (cholinergic acetyltransferase). Because the enzyme is present in the cytoplasm, acetylcholine is synthesized in the cytoplasm, which is then ingested and stored by vesicles. The synthesis of norepinephrine takes tyrosine as the raw material. Firstly, dopamine is synthesized under the catalysis of tyrosine hydroxylase. Dopamine is then ingested into the vesicles, where it is further synthesized and stored in the vesicles, catalyzed by dopamine neurohydroxylase. Dopamine synthesis and norepinephrine 2 steps before Daniel people is exactly the same, just no longer after dopamine into vesicles synthesis of norepinephrine, because stored within the small Tang dopamine excluding beta hydroxylase dopamine. The synthesis of 5-hydroxytryptophan takes tryptophan as the raw material. First, 5-hydroxytryptophan is synthesized under the action of tryptophan hydroxylase, and then 5-hydroxytryptophan is synthesized under the action of 5-hydroxytryptophan (amino acid desatase). The two steps are performed in the cytoplasm. Serotonin is then ingested and stored in vesicles. Decarboxylated isobutyric acid was synthesized by glutamic acid catalyzed by decarboxylation of glutamic acid. The full complement of peptide transmitters is exactly the same as the synthesis of other peptide hormones, which are regulated by genes and produced by translation on ribosomes.
Once the acetylcholine that enters the synaptic gap ACTS on the postsynaptic membrane, it is hydrolyzed by the cholinesterase to form choline and acetic acid, which is then destroyed and promoted, a process called inactivation. After norepinephrine enters the synaptic space and plays a physiological role, part of it is taken away by blood circulation and then damaged and inactivated in the liver. The other part is destroyed inactivation by the action of catecholamine and monoamine oxidase in effector cells. But the presynaptic membrane, for the most part, restores norepinephrine into the axoplasm of the presynaptic membrane and reuses it.
The brain has a lot of acetylcholine, but the level of it goes down with age. Normal older adults have a 30 percent decrease compared to young adults, while alzheimer's patients have a more severe decline, up to 70 to 80 percent. American doctor wootman observed a decrease in acetylcholine in the brain tissue of the elderly and gave them foods rich in choline. Scientists in countries such as the UK and Canada have also carried out research which shows that if enough choline is supplied in a controlled manner, memory loss in people aged around 60 can be prevented. So maintaining and increasing the amount of acetylcholine in the brain is a fundamental way to address memory loss. In nature, acetylcholine is mostly present in eggs, fish, meat and soybeans in the state of choline. These choline must undergo biochemical reactions in the human body before they can be synthesized into the biologically active acetylcholine. In addition, regular use of royal jelly can improve the content of acetylcholine in the brain, thereby promoting the activation of brain nerve conduction function, improving information transmission speed, enhancing brain memory ability, comprehensively improving brain function and delaying aging.
At present, DLDEVELOP co. LTD has developed corresponding ACH Elisa products. To get more information, you could contact our professional staff directly or directly to our website:
https://dldevelop.com/Research-reagent/dl-ach-ge.html
https://www.dldevelop.com/uploadfile/data/DL-ACH-Ge.pdf
