Apolipoprotein A1 (APOA1)
Apolipoprotein A1 (APOA1)
other names：Apo-A1; ApoA-1 Milano; ProapoA-I; Proapolipoprotein A-I; Truncated apolipoprotein A-I
Apolipoprotein A-I the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters.
ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.ApoA-1 Milano is a naturally occurring mutant of ApoA-I, found in a family descended from a single couple of the 18th century.
Sequence length
Sequence:MKAVVLTLAV LFLTGSQARH FWQQDDPQSS WDRVKDFATV YVEAIKDSGR DYVAQFEASA LGKQLNLKLL DNWDTLASTL SKVREQLGPV TQEFWDNLEK ETASLRQEMH KDLEEVKQKV QPYLDEFQKK WHEEVEIYRQ KVAPLGEEFR EGARQKVQEL QDKLSPLAQE LRDRARAHVE TLRQQLAPYS DDLRQRLTAR LEALKEGGGS LAEYHAKASE QLKALGEKAK PVLEDLRQGL LPVLESLKVS ILAAIDEASK KLNAQ
Sub Unit:
Sub Unit:
Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin.
Function:
Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
